Of course, the DR must have a non-automatic safety to be able to close it while the triggers are held back!

My Jeffery .400 has Southgate ejectors and I have many times closed it with the triggers pulled. I closes quite happily, letting down both the tumblers and the ejectors smoothly without any 'clicks' or 'snaps'. The only difference is that when it is next opened it cocks the tumblers, and then it cocks the ejectors on closing.
No problem that I can see.