Watch out!!

MY wife would probably tranquilize the Buff and turn him into an ATTACK BUFF for use on unsuspecting husbands not doing their designated honey-do's!!!!!

And no,if I were after the Buff it would be a 500 with the 2nd shot a CNS try if at all possible.A 500 to the head should create more shock than a 400 if the brain or CNS was not KO'd.But if I had to shoot one coming at me going at the CNS with a 450/400 might be better than shooting into the animals chest with a 500NE.

Read about a fellow who put 7 458WM center of mass shots into a Buff before it went down.A local Doc shot one and said it took 4 shots to stop it. It reportedly died at his feet, 6 feet away. Buff are tough animals indeed--