Well in simple terms..

The 450/400 3” Jeffery was a favorite calibre of legendary hunters like Podoro Taylor, and Elmer Kieth early on. I believe Taylor shot about 1500 Elephants, so he certainly knows what works in the field. Saying that, this cartridge with the right hunter can take any game, with excellent shot placement. The real pleasure here is the recoil, compared to a 470NE. However, this cartridge does not have the “stopping power” of a 470. With that said, it’s my choice for an all around cartridge for medium to large game, but for dangerous game I’ll stick with my 470NE or 577NE. Here is the ballistic data on the 450/400 3" Jeffery.

450/400 3” : Velocity is 2125ft per sec. with a muzzle energy of 4056ft lbs.

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The 470NE is one of those cartridges that replaced the 450NE, and was orginally designed by Joseph Lang abouts 1900c. This calibre was the “adopted” calibre for Rigby’s after the 450’s demise, and as anyone can tell you the 470NE is a calibre of choice to this day for Africa's toughest. However, the 450NE is also enjoying much renewed interest, and is so versatile. It is also a favorite calibre of mine. Here is the ballistic data on the 470 Nitro Express.

470NE: Velocity is 2200 per sec. with a muzzle energy of 5380ft. lbs.

Hope this helps!