375 Flanged sounds good. But I think a 6.5X55 is great elk medicine with the usual barrel twist and 160 gr rn. I can find lots of alternative rounds but my 9.3X74, properly regulated with 285 gr Barnes triple shock bullets would be hard to beat. It would work on large moose and bear, and pigs or whitetail as well. Lots of other alternatives were mentioned but trajectory must be learned no matter the caliber. Still, I think back to the 375 as a good solution. I wouldn't fear much of anything in the woods or on the tundra. Rusty Z