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I've killed elk/wapiti with 6.5x55, 7x57, 9.3x57 and .375 H&H Magnum. I can tell absolutely no difference in the effect on the animal between any of these cartridges.

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9.3,

This would cause me to question your ability to observe. Just a friendly disagreement. But the 6.5x55 with a 140 @ 2600 is NOT in the same killing/power class as the 375 with a 270 @ 2600.

With perfect shot placement, no difference. With less than perfect shot and/or placement, then big advantage to the 375.