Hop,

I think you have answered your own question. In America the double rifle is a novelty not unsuitable for hunting, but far from ideal. Range, weather and vicious terrain often calls for a lightweight, compact rugged firearm.

In the absents of common sense, I would say there are two configurations that I would say meets the “Ideal criteria”.

1: .300 Win or .375 H&H for general big game.

2: .375 H&H or . 450/400 3” for Alaska

Why? Availability of ammo.