I'm sure this has been asked before, but I couldn't find it in my searches. I understand that double rifles were designed around and work best with rimmed/flanged cartridges, however, it seems that most manufacturers are making double rifles for rimless cartridges. What is the downside to a double in 30/06, 300 Win, 375H&H, or 416 Rigby? Is the "danger" in reality or theory?

Example: I'm somewhat of a Ross Seyfried fan and have met him a couple of times. He wrote and sang the praises of the Mauser extractor/controlled feed system for bolt action rifles, BUT his own DG rifle was based on a Remington action. His response? Theory is nice, reality based results are better.

So is DG double in 375 H&H just an accident waiting to happen?