Agree with 500grains, except for buffalo. Even for big old bulls, in my neck of the woods its premium soft-points for the client or resident hunter, and steel-jacketed solids for the PH or guide (almost) every time.

I'll probably remain a Woodleigh fan to the grave, but one of my mates has been getting good results with the new Hornady Interbond bullet in his .458 Lott. This 500-grainer went through the spine of a big bull at the base of the neck and pulled-up under the off-side hide. Still weighed over 425 grains (85%). Not too shabby.......