The .450 # 2 is commonly used as it develops low pressure, in the relm of 32,000CUP. Most of the others develop around 40,000 to 44,000CUP I believe. Compared to the 12,000CUP of modern shotshells even the .450#2 is quite high, but I'd not hesitate to use one for that #2, or a .50/90 Sharps ctg.