It is pure conjecture as I have no African experience but with the previous opinions expressed---
if I had my druthers was hunting PG and there was a chance of Buff or Ele making a surprise appearance I would like be carrying a 450/400 or 375 Flanged Double or similar class DR with solids etc with the scope off and detached .The scope could then be mounted on a low power if and when stalking game.

In a different environment with no similar risks a 375 bolt with softs would seem more than sufficient.

If this seems incorrect or illogical someone please comment.