I've always wondered about the effects of shooting in different areas have on the regulation of double rifles.

For example if you bought a gun made in Austia (or anywhere) and it was regulated with factory ammo what would likely happen if you took that rifle to Africa or Australia or anywhere where the ambient conditions were different....altitude was different, temperature was different, etc.

This would have an impact on how that same factory ammo would perform with a resultant change in poi and regulation......wouldn't it? Has anyone experienced this and if so, what did you do about it?