When is the last time you've been charged by a deer? Mickey was talking about smallbores above. I'm thinking that if you are going to be facing an animal that has a possibility of charging that you wouldn't be using a 7x57R, 7x65R, 333 NE etc.
I beleive his point was that you are considering all DR to be large bores when in fact more smallbore DR's are made and used than largebores every year.