I have a 9,3x74R Chapuis with a 2.5x8 Leupold in their QD mount. It has become my favorite rifle under 40cal.
No doubt the 375 has a little more "paper ballistics" than the 9,3 but I doubt any animal could tell the difference.
The Chapuis only weighs 7 1/4lbs [without scope] and is a joy to carry.
If a 375 H&H double would work flawlessly it would be a great choice as ammo is widely available.
375 Flanged Magnum would be a best seller in new doubles if the ammo was widely available, wish Federal and Chapuis, Krieghoff, Merkel etc could get together and promote the 375 Flanged Magnum.
Double D is correct, I have edited my post to "say" what I mean.