For me there is only one calibre for 'all round use' - that being the 450/400 NE.
Yes she's an old cartridge, might not have as much punch as a lot of newer cartridges, but she's done it all before from antelope right up to Elephants, using the right projectiles no less!
With bonded projectiles like Woodleigh's this makes it an even better proposition, true no genuine stopper, but this old Savana Queen can still do it all even after 125 years of service.
Just my 2c's worth!