DarylS said "I suspect the 300gr. Nosler would be a super bullet for any of these .45 cal rifles for game in NA."

Indeed it is, in fact most thin skinned game are fair targets, Including this African leopard taken with Nosler PP at 2200 fps.

On white tailed deer and similar game the bullet is devastating. With my 1886 shooting Winchester Gold 300 grain Nosler PP from a distance of 110 yards, the bullet took out two ribs going in and 4 ribs going out; essentially destroyed the chest and all in it. This was a 6 point buck and was good eating.
MV was 1850 fps.