I'm sure my bro used a 300gr. Hornady from his .45 3 1/4" Shiloh Sharps on the moose, way back when.
I loaded his ammo at that time, using 62.0gr. Re#7 - for 2,260fps.(IIRC)
The moose was a young one, 18 mo (we call 2 year olds) & ran just over 300pounds in quarters at the butcher.
The shot was a broadside shot and the bullet exited the off side, making a 1" exit hole.
On the hide, surrounding the hole, was a ring of jellied lung tissue about 1" thick x 2 1/2" to 3" in diameter.
I was quite impressed with the penetration.
I suspect the 300gr. Nosler would be a super bullet for any of these .45 cal rifles for game in NA.