Not in North America, but I would choose a 9.3x74R or a .375 H&H Flanged. Either choice will handle anything and everything in any circumstances in North America including brown bear. Great for moose or elk. Over-gunned a little on deer but not too badly.

Add a scope on it and can snipe at hunting ranges with at least one barrel.

My Valmet in 9.3x74R with scope, it is an under and over, would do fine. Put in the 12-bore barrels and you have a shotgun.

I do prefer a side by side. Oneday will have one in .375 ... maybe ...

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From realms of armchair North American expertise, I have always regarded the 9.3 or .338 as the ideal alround North American calibres. So a .333 or .318 would also work well. And be less overgunned on medium sized deer etc. But 250 to 300 gr bullets when needed.