NitroX the 500JRH was put together by Jack Huntington for the purpose of having a relatively light and compact sidearm for use as self defense around dangerous game.

He's taken all sorts of massive bovine game with the 500JRH including Cape Buffalo. The cartridge works great from a 4-5/8" barreled holster gun.
It'll knock steel targets down with no problem. I've beat up a lot of steel with a lot of big bore revolvers. Get your steel and go.
For all it's worth, a 500 would be great on those big bastards up in the NT!