I have both .450 NE and .458 Lott. The Lott shoots with somewhat higher velocities. I use .450 grain mono metals in the Lott given the much shorter case and my desire to keep loads somewhat conservative compels me to avoid hotrodding it. My 450 NE is a SxS double and I am limited by the speed /loads that regulate well in it. I have found the 480 grain Woodleighs work spectacularly well in this cartridge and rifle combo.

Daryl is absolutely right..... There is no wrong answer. But there is a lot of room to play and experiment!!!