I have only taken one Buffalo and that was with a 416 Rigby. Just my history. Would I use a 9.3 X64 -The closest a 9.3 get to the 375 and there is still a gap between them- on a Buff. No. Not now. If I had one and used it as much as I did the 308, 30-30, 303 and 270 in my younger years then probably would but it would be loaded with Woodleigh Hydros.

What it comes down to is, are you very competent and confident with the rifle and cartridge?