A few months ago while on a hunt with the Double Rifle Shooters Society I handled and fired 2 rounds from a Krieghoff 500/416. At about 40 yards a soft and a solid were touching.
The 500/416 is a good cartridge giving ballistics equal to the 416 Rem Mag and the 416 Rigby.
I would prefer a 500/416 Krieghoff Double to ANY 416 bolt rifle for any animal I would hunt with a 416.
I would definately have the Krieghoff fitted with a scope in QD mounts. Even if I did not use the scope with 400 grain bullets, I would have a load with 300 grain bullets for lesser big game. With 300 grain bullets and scope, the 500/416 would make an excellent leopard rifle. For lion I would use 400 grain bullets.