Myself I would prefer a 180 gr projectile in a .300 H&H double rifle.

Most however I guess would be regulated with a 220 gr projectile ???

Curl on here has a .300 Magnum double rifle, I am not sure what his is regulated with ???

I would use a .300 DR for plains game and HOPE it is capable of longer shots as well as normal DR ranges, especially if scoped. Therefore my choice of a 180 gr.

If choosing a heavier bullet such as a 220 gr it would normally be for larger than medium sized game, and I would probably prefer a larger calibre then.

Really up to the user.