I don't know.

A couple of years ago I beat the crap out of myself trying different loads in a friends 577 2.75" BPE to see what it liked.
28 round over a period of about 4.5 hours. Shot over a rest at a bench, but on my knees to enable the gun to recoil and torque.
Got home and got out a couple of bottles of Windhoek (hhhhmmmmmmmmmmmmmm Windhoek lager) and noticed that I had the tremors when trying to use the bottle opener.

That was only (only ?) with a .577 BPE. I don't know if I could own a .600 Nitro. I'd stand in line all day to fire one, but how many times, I don't know.

.