The size of the exit hole? Dead is dead.

I do prefer 1. An exit hole; 2. An exit hole that is larger than the entry hole to promote blood loss, and also as an indicator that my bullet did more than poke a narrow hole through the target, i.e. I want some evidence that "some" tissue destruction happened on the way through.

Smaller, deer sized game, 200 - 300 pounds don't seem to need a nasty medium bore like a .375 to make an impression on them, but whatever floats one's boat is a good thing! I once hunted caribou with a gent that pasted one broadside at 150 yards with a .300 Weatherby magnum. He had field dressed it and hauled it back to the trucks by the time the rest of us returned with our caribou. One of the older guys got incensed because when he looked at the caribou, the entire left side of the rib cage was missing, and he railed on about the Weatherby shooter's weird field dressing method of removing the entire side of the animal! The old gent grabbed the antlers and flipped the caribou over so the missing side was hidden from view from any passers by in the event they may have thought the group didn't know how to field dress an animal. We all smiled about that one for a few years! On the other extreme, we had another gent shooting a .45-70 using a heavy slow bullet that plowed a hole through his caribou, but without the dramatic effect of a disintegrated rib cage. The hole was closer to golf ball size on the exit, and maybe less, but the caribou was still just as dead. Nobody was using FMJ bullets, so there was always a reasonable exit hole.