I had one of these. Here goes with what is strictly my opinion for whatever that may be worth. Your mileage may vary:

The tilting block makes them incredibly strong from a pressure handling perspective. They can be regulated across the horizontal plane via a wedge fitted between the barrels somewhere near mid point along the length of the barrels. Mine did not pattern well on the vertical axis. To solve this, I gave the muzzle a light careful rap with a 2 pound ball peen hammer to bring the barrels in sync so they would shoot side by side. At this point they could be easily regulated to give impressive composite groups. The muzzles are held together with a soft brass? yoke.

Positives:
1. Fairly easy to regulate
2. Strong tilting block action
3. Very heavy thick steel barrels
4. Extremely impressive accuracy from individual barrels
5. Amazing composite groups albeit after some fiddling
6. Wonderful removable Blaser saddle mount for scopes
7. Very well designed high visibility express sights
8. Incredible wood

Negatives:
1. Grip shape and trigger guard not conducive to dealing with heavy recoil - for me, the trigger guard would slam painfully into my second finger
2. Tilting block took some getting used to. Not as straight forward as dealing with a traditional break action
3. Ergonomics: not sure I can put my finger precisely on this point: to me, the gun did not feel as lively as the Merkel nor the Heym
4. Scope mount and rings very expensive
5. Extractors - I prefer ejectors, but again, a personal choice

In the end, I sold my S2 in favour of the Merkel 140a in .470, and subsequently graduated to the Heym .500NE I presently own.

Overall, I liked the S2 very much. The ergonomics for me was what caused it to be sent down the highway in favour of something else. I can't say that they would be everyone's cup of tea or not. One would be best off to handle one for one's
self. As they say, "your mileage may vary"