Folks ,

I have had the opportunity to hunt white tail deer with the 6.5 x 53R with the 160 grain bullet and have had excellent one shot harvests . The long for caliber bullet has remarkable penetration with it's cross sectional density . But if one is going after hog or even the Texas exotics , I agree with the 405 for the Taylor Knock Out power . Those animals are tough and will absorb quite a bit of kinetic energy . The 405 within your pressure constraints will be close to 3500 foot pounds if you go 45,000 to 48,000 . Add your Barnes 300 grain TSX and it should work well to 120 - 130 yards on the hog or heavy exotic . Jim