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Probably the most versatile and most popular medium calibre today is the 9.3x74R and pretty good for everything in NA.

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..........................................Absolutely! It is versatile and is under 50K PSI chamber pressure. I like it enough that I own two double rifles so chambered, and it have become my all around double for North America, and a back-up for my 470NE double for traveling! The 9.3X74R would and has already been my pick!