I have between 1000 and 1200 rounds fired through my Chapuis. Two hundred or so factory rounds, the rest handloads.
My Chapuis was factory regulated with RWS 293 gr.TUG. It shoots good with 232 Norma, 286gr. Sellier and Belliot [sp] 286gr Norma Alaska, 286gr.RWS Soft Point, Superior Ammo loads with 286 Woodleigh Softs and Solids, 286gr. Nosler Partitions, 300 Swift A Frames,320 Woodleigh Softs and Solids, and my reloads with 270 Speer, 285 gr. Hawks, 286 Nosler Partitions, and 286gr. Woodleigh Softs and Solids.
With many of these loads I can use the same zero to 200 yards. While some loads shoot better than others all shoot good enough to hunt big game with.
The www.superiorammo.com loads with 286gr Nosler Partitions, and the Woodleigh Softs and Solids shoot the best. Their 300gr Swift A Frames shot good too.
I have not had any problems with my Chapuis.

A friend of mine just bought a Chapuis in 470, I will keep us updated on its performance.