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Differences of opinion are what make this interest of ours so fascinating. However, I believe that you are missing the point entirely. A reasonably proficient shot, with a .416 or a .500-416, launching a 400 grain bullet at 2400fps, will make consistent killing hits out to 300 yards, because of the relatively flat trajectory, and high sectional density, of that projectile. Thus these cartridges can serve as dangerous game ones at close quarters, and can also put down an antelope way out and beyond. This is not a reasonable expectancy for a .450NE, a .470NE, or a .500 NE.

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Valid point, I'll pay you that one.

However does 375 and maybe 404J fit the bill ?
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I think you missed this post;

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Given the Manufacturers who chamber it, I'd say it still serves it's function; giving buyers a reason to order an extra set of interchangeable barrels when the order their .500NE double

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If you take everyones favourite DG double, the S2 yes you can buy a spare set of .375H&H barrels and scope to have sitting in the case until needed and worry about extraction of a rimless case, or buy a set of .500/.416 barrels, scope them for shooting out to 300 yards whilst still having the extra confidence of another 100g of lead and a rimmed case.