Modern powders lack the low density (bulk) of the old ones, meaning they don't take up enough case space when loaded at maximum pressures and therefore need a filler of some sort - or the use of a powder that ignites readily, not needing a filler.

For me, IMR 3031 is too fast burning for large cases and becomes somewhat erratic in them at higher pressures.

The only powder I can think of that you can possibly get away with no wad, is H4895, yet it-too works best with a wad of some sort.