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I believe it was Selous who used and suggested 480gr. to 500gr. hardened lead bullets in the .450 BPE for use on elephant.(or was it Taylor who suggested this?) Of course, too-slow a rifling twist could eliminate the heavier bullet's use due to stability problems.

Smokeless equivalent loads kick considerably less than black - going to a heavier bullet to compensate might help with regulation - as Andreas suggested.

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I believe Selous used a .461Gibbs with 90grains blackpowder and a 570grain coppercoated leadbullet for elephants for a peroid of time with great succes..