Daryl notes the fatory specs, but we need here a discussion of the actual performance of factory loads in both;

Seems .375 loads generally meet or at least get very close to factory spec. But 9,3x74R? Have heard reported that some 9,3x74R factory loads fall very short of the standard velocity spec and more approach performance of the 9,3x57 {286 @ 2150 fps +-}.

Hopefully some comment here by those who have chrono'd a multitude??

Also, a 200 fps velocity spread between the two might not show in many cases on game at 50 yards, but does represent about +- 100 yard difference in useful field trajectory.

This discussion is a little like the enjoyable .300 Savage or .308 Win vs. .30-06 discussion that never ends, which is to say that the '06 will ALWAYS beat the smaller-bottled rounds for all-round field use just plain due to the amount of velocity it can generate and the flatness of trajectory thereby created.

Of course if deer at 100 yards is on your plate the diference between 9,3x74R and .375 H&H is non-existent. The critter will never know what sent him to the deepfreeze. Hitting at longer range, especially unknown ranges in the wind might very well be noticeable.

IF, did I say that...yes, IF a guy can shoot well enough at the farther ranges to realize the difference.