I have shot several Buffalo with them..I loaded some RL-15 with 350 gr. woodleigh softs at about 2375 FPS and they worked just fine..I also used the 450 gr. 416s and shot 9 Buffalo with them last year..They are an excellent bullet. I used the round nose version..this year I will use the PP in the same weights, they seem to have more penitration in my limited use of them....