Regarding being careful selecting heavy bullets, you will eventually get to a brief post by 500 Grains, who has done a bunch on the topic. He is a fan of mono metal flat nose solids, and not one of those who once aware of the benefits who then think Woodleighs stink.

He believes that when one moves to a mono flat nose solid, it ought to be 10% lighter than the "standard" bullet. So for a .458" rifle, it ought to be 450grs, or for a 375H&H 270grs, for a 416 then 370grs or so.

I think he's generally right but each rifle's twist should lead to the answer.

JPK