In my 45/70 I've been shooting a handload that replicates the remington factory ammo and the rifle will shoot clover leafs at 50 yards. I've tried the leverevolution stuff and the shots were already crossing at 50 yards. Your results may vary, but shooting the remington I didn't have to mess with the jack screws at all.
On my 30-06 version I found the Federal 150gr to hit 1/2 apart at 50 without re-regulating.