There is no doubt it would work, its just a matter of taste. The 'enemy at the gates' associations of your round would make it unattractive unless, perhaps in a Baikal. The advantages of a zillion different available projectiles are less attractive, when you have to pursue regulation for each bullet you try. On the other hand, a Baikal in this calibre would be pretty neat. - Imagine perhaps a Siberian hunt?

I would much rather have a .303 double - because doubles for me are about the glamour of past times in India and Africa, and the .303 is a heritage item here.