Ideally, the answer is yes. They're not supposed to cross. The idea is that the POI of both barrels will be close enough to POA at any useful hunting range that the difference can't matter. If a double is cross-firing much at all, that isn't possible.

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In the meantime, anybody have info on the regulation ranges, ammo and POI of the various makers? Certainly the custom makers can/will regulate for a specific load, but I am asking about the production makers.

Anybody know?

All double rifles regulated by the makers (which of course excepts the "adjustable" wedge stuff), are regulated for a specific load. There's no other way. The maker will specify which brand of factory ammunition was used or, if a handload, what components were used. Sometimes you do have to ask. They don't always use the same load in a given caliber. It's a matter of what's available at the time, what the customer requests, or where the rifle is expected to be sold. For example, most Chapuis 9.3s are regulated with 286 grain Norma Oryx, but some are regulated with lighter bullets for some reason. Heym regulates their .450/.400s with Hornady ammo, even though Romey and Kynoch are easier to get in Germany. Last I heard Holland's was using both Romey and Kynoch.

Pretty much all the makers I'm familiar with regulate at 50 meters if the rifle is regulated with irons, and 100 if it is regulated with a scope. Some use a sitting rest, while others use a standing rest.