I would assume In a Double the lighter stuff at higher velocity would be a pain to regulate for the 338 Wildcat. The heavier 250 should be the better Double bullet with more predictable path/trajectory and penetration while the primary advantage of the 225 gr would be the flattened trajectory at distance.. The 225 gr 338 ammo in bolt guns does well for me at 300+ yards for elk and I have killed with this weight bullet at ~350 yds shooting ridge to ridge but that scenario doesn't jive with Double bullet regulation at long distance and the advantages of a Double.