The .480Ruger is spec'd at a max pressure of 48kpsi. It's also based on the 45-70 case so it should produce similar thrust to a hot 45-70. As long as it's loaded to spec and not hot-rodded past it's intent, it seems like a good choice. And it's a real pistol round, unlike 45-70. 45-70 requires a pistol nearly as heavy as a rifle! And 480 is a capable big game round to boot.