Depending on the action and rifle weight, yes and no.

On the other hand,

A .50-110 would be OK, I guess, but a .50/90 Sharps would be better, easier to load for and easier for brass and dies. (.50 2 1/2" straight case)-

or the .50 3 1/4" for that matter.

With pressures at or under 30,000CUP, from a 24" bl. .50 3 1/4"you could drive:
425gr. at up to 2,294fps and 515gr. at 2091fps - both in lead.

The 3" .500 NitroExpress is listed for 2,246 at 40,500PSI

The .50 Alaskan is also a good one and used blown out .348 Winch brass.

My data for that one in 22" using Starline brass runs 435gr. lead to 525gr. lead, with 450gr. and 500gr. jacketed in the middle - all at pressures under 36,000CUP.
435gr. at up to 2,089fps
450gr. Barnes FP - 1,940fps
500gr. JFP - 1,854fps
525gr. lead - 1,852fps

My friends, those speeds are very close to or exceed .500 BPE loads with heavier bullets. That .50 Alaskan is NO slouch.

My bother's got his .50 Alaskan Shiloh Sharps (McGowen bl.) shooting just over 1" at 100 meters off the bags using Soule Tang and Sharps Aperture front sight. We were shooting 5 groups - with black powder yet.