A friend of mine has a 50 Alaskan made up on a AYA shotgun action.

I've hunted with it a few times, and taken a scrub bull, a handful of donkeys and a few pigs with it
Regulated for 440 gr Woodleigh, with 60 gr of 2208 (varget), a low pressure load that only does 1700 fps, but works well in the bush..

Cheers
spinna