Bill - I've taken both moose and elk with the RN version of that bullet driven at 2,300fps and for me, it's tossup between it and the original style Barnes 400gr. Spitzer.\

Rib shots are no brainers with just about any bullet, but the last moose shot, was at about 95 yards (while we were eating lunch right from camp). The Hornady bullet took him above the left eye, coursed lengthwise through his brain into the spine, smashing 3 vertebrae then exited out the back of his neck. I as impressed.

It will handle lesser game quite easily. 200 yards is easy range. Past that, one must practise a bit more.