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If you really need to stop something with claws and that bites, and if time limits precise shooting, go for a S&W 500 w/4" bbl. I've used mine a couple of times to stop animals with bad intentions, and, no, no handgun will drop an animal in its tracks, unless brain shot. However, a 500-gr. bullet will make them pause and give you time for a well-aimed second shot.

if more info needed, pm me.

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