There is large game and there is large game. I would not disrespect a large game animal by shooting at it with a flurry of pellets, hoping that one or two or even three might not only hit in line with the lung cavity somewhere, but penetrate to the vitals at well. Do as you will, but be aware of their failings. Pellets into the guts don't make for a nice butchering job, either.
; Use them for home defense? - I'd think a load of 6"s might be better inside, and reserve the buckshot for outside. I do think they're OK for blowing maggots off the fence - appropriate might be a better word than OK.