Spot-on, Steve and Luckydog - one must know one's limitations & self-imposed practical limits.
; I feel a certain respect for the big game animals I hunt, and feel anything over about 300 yards is too far. Too much can go wrong when hunting and usually does, especially on moose in the bush - across ponds, cut-blocks and such. Intervening underbrush that is unnoticed, a quick stride forward or sideways at the instant the trigger breaks all makes for poor hits which otherwise would have been perfect. A moose moves about 4' in one step - if that happens as the trigger breaks, your 270 or 300gr. aimed at the shoulder just hit him in the butt or guts. The longer the range, the worse the hit. 300yards is pretty easy, even with irons - if one practises with them. Even my little m94 .375 Winchester is certain at 300 meters at the range, every shot on the ram silhouette, but past 200 meters, I cannot be certain of a hit within 3-4" of my aiming point with it's irons and would refuse anything further - with that rifle and it's sights.
; Most all .27 and larger calibres have enough power to properly kill moose or elk at 300 yards or further with perfect hits. There is just too much chance of something going wrong to make longer shots - movement or obstructions - your's or the animals.
; I said I would refuse anything further & that's the truth - whole truth be known, Only once did I shoot beyond 100 yards on moose, long time ago, and now, moose elk, bear or deer are all taken inside 100 yards. I'm in the bush to hunt, not to plink at long range like I do in the gopher fields. If you truley hunt, revel in getting close - there is an enormous satisfaction in the hunt - little in simply killing, which is what long range sniping amounts to - it isn't hunting in my opinion - more of a dirty trick on the animal. Sorry if that raises hackles.