Question Will the point of impact change if the rifle is sighted in with a muzzle brake on and then the brake is removed?

The answer from firing a couple hundred muzzle brake equipped rifles: Yes it will sometimes, no it won't sometimes. Some rifles will and some won't. You just gotta check your rifle and see if it will. There are some variables.

I only own one brake equipped rifle-a .308 Norma Mag. It was given to me as a sales incentive. It will shoot to the same point using Factory Ammo with or without the brake. The point of impact changes, high if I remember right with my 180 gr. hand loads. It's probably been 10 years since I did that test and I am now over 60 so am allowed to disremember such details.

Also factory groups were tighter without the brake. But with the brake the rifle still met the required accuracy standard for that particular make rifle...3 rounds under 1/2 inch, 5 rounds under 1 inch.

My handloads all group around 3/4 inch with or with out the brake. Taking the brake off has no affect on accuracy with that rifle and my handloads.