I have shot many deer with a shotgun and slugs, one with my 375 H&H, and one with my 460 WBY. Now I am no forensics expert but what I can tell you is that comparing the 460 to the shotgun is that the entrance and exit holes were very similar the big difference was what happened inside the deer. With the shotgun it is a normal wound you would expect with a .50 slug at 1200fps (or somewhere in that range) but with the 460 ( 400gr) it was like gutting a boll of soup (50 yards distance or so on both shots). The 375 well it looked like a 375 small hole in bigger hole out and animal was dead in its tracks. Surprisingly with the 460 I double lunged and hit heart it still went about 20 yards but than again I am used to a shotgun and I try to hit just behind the shoulder blade in which case it always takes them a few yards before they figure out they are dead.
Any way that’s just what I remember I didn’t have my tape measure on me so the only thing I really know for sure is that the deer were killed quickly and I had a good hunt.