The 378 is a great long range cartridge for big game such as elk and moose.Real big bore impressive knockdown power.

I feel it has no advantage over a 375 H&H inside of 200 yds for dangerous game and the disadvantage of increased recoil.

I think that bullet diameter and penetration of the 375 on DG is perfectly adequate vs a 378.The 375 Wby is nice but I don't know that the extra 100 fps is worth it. I don't think the animal can't feel the difference.