You question will cause all types of indesgestion on this site--WE have beaten this topic to death on numerous blogs...

The 375 is typically more user friendly,,ie; recoil, trajectory, all around gun...

With the .416, whether Rigby, Remington, Taylor, or whatever--has considerably more knock down and it is noticeable when hunting the big stuff...

As to Remingtons, some hate them, some love them... I have used them most of my life and have literally shot thousands of rounds through them without so much as a hickup.. apparently others can't same the same..I have taken a custom shop .416 Remington to Africa on three hunts--worked great.. I have other much more expensive bolts, but I have never had a problem with it..fits me great..therefore I shoot good with it and am confident as well plus if it gets lost or damaged I won't have a stroke like I would if a 6 or $8,000. custom was in its place.

If you plan to use it more for dangerous game I would suggest a controlled feed rifle--if you wait a few months you will be able to get the NEW AND IMMPROVED Winchester model 70--If this does happen I plan to buy a few just for the actions if nothing else..

I have a similar predicament as I am going back in May of '08--I plan to take my double W/R 470 and one other gun... As I will be hunting dangerous game and need to shoot bait animals as well.. I have been kicking around taking a .375 this time instead of my .416 simply because it is a bit flatter shooting and if I have a longish shot at a croc.. might be to my advantage to have the .375..

Good Luck

Ripp