The big bores simply make a different kind of wound..It is a longated large core cut out of the animal, it bleeds profusly and does not damage a lot of meat by comparison and the wound channal is pipelike in design.....

The high velocity rounds shock, destroy surrounding tissue and meat. The wound channal is bulbus in design...

The Hi-vel calibers can kill like the hammer of Thor, but they also tend to fail on ocassion by exploding on the surface of the animals skin..They seem to me to do very well on light, high strung animals, but not so good on big heavy boned animals...where the big bores do much better..

I like to use a big bore like a 375 or 416 on deer and elk, as it does save meat waste and kills with 100% surity, albeit they may run a 100 yds or so, but they will leave a good blood trail, that a blind man can follow......

I won't argue the point of which is better, as both have their place in the scheme of things